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WHAT IS THE RELATIONSHIP BETWEEN AGE AND ASPIRATION QUALITY FOR BONE MARROW?

1) The cellularity of marrow declines with age
2) The cellularity of marrow per / mL declines with increasing aspiration volumes.

 

 

Muschler G et al “Age- and gender-related changes in the cellularity of human bone marrow and the prevalence of osteoblastic progenitors” Journal of  Orthopaedic Research Volume 19, Issue 1, pages 117–125, January 2001 Pang W et al “Human bone marrow hematopoietic stem cells are increased in  frequency and myeloid-biased with age” PNAS vol. 108 no. 50 20012–20017